HitPredict

Interactor 1: RADI (P35241)
Radixin
Gene: RDX

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003779 - actin binding GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 583 Hs			1 7388
+	Hs
		547281 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		547015 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		719702 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		546969 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		719679 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		297816 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		K0754_HUMAN (757-1741): 1.73e-10: 70.9: 10.05
+	Hs
		521459 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		547057 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		547044 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		719709 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		640102 MOES_HUMAN (1-583): 2.8e-161: 474: 80.96		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		640097 MOES_HUMAN (1-583): 2.8e-161: 474: 80.96		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		505537 EPB41_HUMAN (3-553): 1.19e-125: 392: 20.48		SPTB1_HUMAN (3013-4737): 1.1e-28: 131: 8.92
+	Hs
		719451 MERL_HUMAN (2-583): 1.72e-151: 450: 45.30		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Dm
		574805 MOEH_DROME (2-583): 1.27e-147: 439: 58.29		ACTN_DROME (5541-6014): 3.94e-09: 65.9: 11.42
+	Hs
		505631 EPB41_HUMAN (3-553): 1.19e-125: 392: 20.48		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		963454 E41L3_HUMAN (2-441): 2.82e-109: 353: 21.80		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80