HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: DTX3L (Q8TDB6)
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)
Gene: DTX3L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 740
+	Hs
		896339 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		919797 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		895856 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		1254722 UB2D4_HUMAN (1-51): 1.33e-28: 101: 39.22		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		849380 UB2D1_HUMAN (1-51): 1.71e-28: 101: 39.22		DTX3L_HUMAN (1-740): 0: 1213: 100.00
+	Hs
		919774 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		DTX1_HUMAN (490-739): 3.16e-121: 378: 33.70
+	Hs
		919770 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		DTX2_HUMAN (490-739): 9.93e-121: 377: 37.14
+	Hs
		895839 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		DTX1_HUMAN (490-739): 3.16e-121: 378: 33.70
+	Hs
		1205017 UB2D4_HUMAN (1-51): 1.33e-28: 101: 39.22		DTX1_HUMAN (490-739): 3.16e-121: 378: 33.70
+	Hs
		849361 UB2D1_HUMAN (1-51): 1.71e-28: 101: 39.22		DTX1_HUMAN (490-739): 3.16e-121: 378: 33.70
+	Hs
		895835 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		DTX2_HUMAN (490-739): 9.93e-121: 377: 37.14
+	Hs
		1200380 UB2D4_HUMAN (1-51): 1.33e-28: 101: 39.22		DTX2_HUMAN (490-739): 9.93e-121: 377: 37.14
+	Hs
		849356 UB2D1_HUMAN (1-51): 1.71e-28: 101: 39.22		DTX2_HUMAN (490-739): 9.93e-121: 377: 37.14
+	Hs
		896484 UBE2N_HUMAN (1-51): 4.56e-24: 90.8: 50.98		DTX1_HUMAN (490-739): 3.16e-121: 378: 33.70
+	Hs
		896336 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		DTX3_HUMAN (552-739): 8.65e-95: 300: 54.45
+	Hs
		72146 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		DTX3_HUMAN (552-739): 8.65e-95: 300: 54.45
+	Hs
		919787 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		DTX3_HUMAN (552-739): 8.65e-95: 300: 54.45
+	Hs
		895846 UB2D3_HUMAN (1-51): 6.77e-29: 102: 35.29		DTX3_HUMAN (552-739): 8.65e-95: 300: 54.45
+	Hs
		1238409 UB2D4_HUMAN (1-51): 1.33e-28: 101: 39.22		DTX3_HUMAN (552-739): 8.65e-95: 300: 54.45
+	Hs
		849372 UB2D1_HUMAN (1-51): 1.71e-28: 101: 39.22		DTX3_HUMAN (552-739): 8.65e-95: 300: 54.45