HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: RN185 (Q96GF1)
E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)
Gene: RNF185

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 192
+	Hs
		896353 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RN185_HUMAN (1-192): 2.35e-56: 178: 100.00
+	Xl
		1140146 Q8AVM8_XENLA (1-97): 4.07e-34: 117: 96.91		Q5XGX4_XENLA (1-192): 1.06e-55: 176: 91.15
+	Hs
		919826 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RN185_HUMAN (1-192): 2.35e-56: 178: 100.00
+	Dm
		854593 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		Q9VXP1_DROME (15-192): 4.58e-51: 167: 58.43
+	Dm
		854587 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		Q8IR26_DROME (15-191): 8.57e-45: 151: 52.54
+	Dm
		854586 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		Q8IQM1_DROME (22-191): 3.65e-40: 135: 40.59
+	Hs
		896364 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RNF5_HUMAN (15-173): 2.18e-37: 129: 60.38
+	Hs
		72156 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		RNF5_HUMAN (15-173): 2.18e-37: 129: 60.38
+	Hs
		919838 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RNF5_HUMAN (15-173): 2.18e-37: 129: 60.38
+	Hs
		896381 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		TRI39_HUMAN (12-144): 3.88e-26: 106: 18.80
+	Hs
		72168 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		TRI39_HUMAN (12-144): 3.88e-26: 106: 18.80
+	Hs
		896395 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		AMFR_HUMAN (27-171): 2.12e-24: 101: 19.18
+	Hs
		919712 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		TRI26_HUMAN (26-132): 1.42e-27: 109: 23.48
+	Hs
		919828 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RN170_HUMAN (26-191): 1.11e-28: 109: 18.64
+	Hs
		919822 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		TRI11_HUMAN (27-130): 9.09e-27: 107: 25.00
+	Hs
		584923 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RO52_HUMAN (26-144): 2e-26: 106: 20.17
+	Hs
		919870 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		TRI39_HUMAN (12-144): 3.88e-26: 106: 18.80
+	Hs
		919902 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		AMFR_HUMAN (27-171): 2.12e-24: 101: 19.18
+	Hs
		749302 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		BRCA1_HUMAN (38-88): 2.19e-11: 64: 35.29
+	Hs
		749339 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		BRCA1_HUMAN (38-88): 2.19e-11: 64: 35.29