HitPredict

Interactor 1: RFC2 (P35250)
Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)
Gene: RFC2

Interactor 2: DCC1 (Q9BVC3)
Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog)
Gene: DSCC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0031390 - Ctf18 RFC-like complex GO:0032508 - DNA duplex unwinding GO:1900264 - positive regulation of DNA-directed DNA polymerase activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 354 Hs			1 393
+	Hs
		722030 RFC4_HUMAN (1-349): 1.14e-89: 275: 32.78		DCC1_HUMAN (1-393): 2e-177: 501: 100.00
+	Hs
		777916 RFC5_HUMAN (18-353): 1.12e-88: 271: 35.21		DCC1_HUMAN (1-393): 2e-177: 501: 100.00
+	Hs
		778028 RFC3_HUMAN (37-346): 4.73e-64: 209: 23.24		DCC1_HUMAN (1-393): 2e-177: 501: 100.00
+	Sc
		634048 RFC3_YEAST (25-341): 2.86e-82: 255: 34.57		DCC1_YEAST (34-389): 1.96e-136: 396: 20.84
+	Sc
		634056 RFC4_YEAST (33-346): 6.69e-79: 246: 60.44		DCC1_YEAST (34-389): 1.96e-136: 396: 20.84
+	Sc
		634057 RFC2_YEAST (18-346): 3.98e-78: 245: 34.39		DCC1_YEAST (34-389): 1.96e-136: 396: 20.84
+	Sc
		634047 RFC5_YEAST (37-345): 1.96e-75: 238: 24.71		DCC1_YEAST (34-389): 1.96e-136: 396: 20.84