Interactor 1: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 25184681, 10783165
Identification Methods affinity chromatography technology, biochemical
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT
Common GO terms GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1148
Hs

1 1863
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024