HitPredict

Interactor 1: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1148 Hs			1 126
+	Hs
		722208 RFC1_HUMAN (1-1139): 0: 608: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707537 RFC1_HUMAN (1-1139): 0: 608: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Sc
		355883 RFC1_YEAST (268-1148): 1.2e-125: 408: 29.95		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355471 RFC1_YEAST (268-1148): 1.2e-125: 408: 29.95		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		1087205 ATAD2_HUMAN (211-1119): 3.49e-75: 275: 10.93		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918455 ATAD2_HUMAN (211-1119): 3.49e-75: 275: 10.93		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		737348 LONM_HUMAN (275-1000): 2.34e-69: 253: 9.59		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		721962 RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		721995 RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		777870 RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707542 RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		722120 RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707536 RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Sc
		355882 RFC3_YEAST (572-928): 1.28e-76: 258: 21.25		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355470 RFC3_YEAST (572-928): 1.28e-76: 258: 21.25		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sc
		355907 RFC4_YEAST (583-908): 1.25e-73: 249: 20.53		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355503 RFC4_YEAST (583-908): 1.25e-73: 249: 20.53		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sc
		355909 RFC2_YEAST (565-884): 1.24e-61: 216: 18.68		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355505 RFC2_YEAST (565-884): 1.24e-61: 216: 18.68		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		707715 ATAD5_HUMAN (494-707): 4.08e-36: 151: 25.96		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41