HitPredict

Interactor 1: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35850772
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1148 Hs			1 1537
+	Hs
		1162751 ATAD2_HUMAN (211-1119): 3.49e-75: 275: 10.93		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		722014 RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		777900 RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		722133 RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26		DOT1L_HUMAN (1-1537): 0: 2441: 100.00