HitPredict

Interactor 1: CD22 (P35329)
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Gene: CD22

Interactor 2: TLR6 (Q9EPW9)
Toll-like receptor 6 (CD antigen CD286)
Gene: TLR6

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ig_3~LRR_8
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 868 Mm			1 795
+	Mm
		722906 CD22_MOUSE (1-868): 0: 595: 100.00		TLR1_MOUSE (27-795): 7.28e-124: 392: 66.54
+	Mm
		722910 CD22_MOUSE (1-868): 0: 595: 100.00		TLR2_MOUSE (5-781): 7.16e-96: 318: 29.29
+	Mm
		722909 CD22_MOUSE (1-868): 0: 595: 100.00		TLR5_MOUSE (10-793): 1.35e-80: 278: 16.92
+	Hs
		590613 CD22_HUMAN (19-868): 1.88e-168: 512: 58.73		TLR10_HUMAN (26-783): 5.64e-106: 345: 47.11
+	Hs
		237425 CD22_HUMAN (19-868): 1.88e-168: 512: 58.73		TLR5_HUMAN (10-792): 1.83e-78: 272: 18.47
+	Mm
		722899 CD22_MOUSE (1-868): 0: 595: 100.00		TLR7_MOUSE (20-666): 3.45e-28: 123: 14.16
+	Mm
		1143686 SN_MOUSE (17-749): 2.14e-65: 241: 17.22		TLR1_MOUSE (27-795): 7.28e-124: 392: 66.54
+	Hs
		1073329 SIG10_HUMAN (314-867): 8.2e-36: 147: 19.50		TLR1_HUMAN (27-790): 6.7e-124: 392: 59.92
+	Mm
		1265315 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR1_MOUSE (27-795): 7.28e-124: 392: 66.54
+	Hs
		237434 SIG11_HUMAN (395-771): 2.98e-41: 163: 22.38		TLR5_HUMAN (10-792): 1.83e-78: 272: 18.47
+	Mm
		1265318 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR2_MOUSE (5-781): 7.16e-96: 318: 29.29
+	Mm
		1265316 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR5_MOUSE (10-793): 1.35e-80: 278: 16.92
+	Mm
		292557 ROBO1_MOUSE (36-393): 1.14e-21: 103: 9.98		SLIT3_MOUSE (23-642): 7.5e-57: 213: 14.99
+	Hs
		296682 ROBO1_HUMAN (63-777): 8.4e-45: 177: 12.72		SLIT2_HUMAN (112-595): 1.36e-27: 122: 14.72
+	Dr
		1265014 Q90Z70_DANRE (13-402): 2.63e-16: 86.3: 11.27		Q9DE36_DANRE (24-404): 1.63e-41: 166: 17.92
+	Hs
		120171 SIG11_HUMAN (395-771): 2.98e-41: 163: 22.38		TLR4_HUMAN (10-292): 2.45e-15: 82.3: 15.86
+	Hs
		179956 SIG11_HUMAN (395-771): 2.98e-41: 163: 22.38		TLR3_HUMAN (255-582): 5.95e-15: 81.2: 12.12
+	Hs
		179954 SIG10_HUMAN (314-867): 8.2e-36: 147: 19.50		TLR3_HUMAN (255-582): 5.95e-15: 81.2: 12.12
+	Hs
		1297092 SIG10_HUMAN (314-867): 8.2e-36: 147: 19.50		TLR8_HUMAN (267-645): 6.97e-10: 65: 10.96
+	Mm
		1265317 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR4_MOUSE (277-632): 7.51e-09: 61.5: 10.99