HitPredict

Interactor 1: CRFR1 (P35353)
Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Gene: Crhr1

Interactor 2: UCN1 (P55090)
Urocortin (Corticotensin)
Gene: Ucn

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

The method score is based on:

Property	Details
Experiments	9423932, 24290358
Identification Methods	pull down, cross-linking study
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	7tm_2~CRF, CRF~HRM
Common GO terms	GO:0007218 - neuropeptide signaling pathway GO:0007631 - feeding behavior GO:0030425 - dendrite GO:0043025 - neuronal cell body GO:0043524 - negative regulation of neuron apoptotic process and 2 others more... GO:0043950 - positive regulation of cAMP-mediated signaling GO:2000252 - negative regulation of feeding behavior
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	415
Rn

1	122

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024