HitPredict

Interactor 1: HRH1 (P35367)
Histamine H1 receptor (H1R) (HH1R)
Gene: HRH1

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 487 Hs			1 347
+	Hs
		723002 HRH1_HUMAN (1-487): 1.11e-118: 358: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		723001 HRH1_HUMAN (1-487): 1.11e-118: 358: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		436949 ACM4_HUMAN (2-486): 3.62e-88: 279: 24.54		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		436948 ACM4_HUMAN (2-486): 3.62e-88: 279: 24.54		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		445811 ADA2A_HUMAN (2-484): 9.91e-81: 260: 21.90		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		436885 ACM2_HUMAN (19-485): 7.93e-83: 265: 26.38		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		436947 ACM4_HUMAN (2-486): 3.62e-88: 279: 24.54		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Mm
		897202 DRD2_MOUSE (1-485): 1.11e-83: 266: 23.34		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Hs
		445810 ADA2A_HUMAN (2-484): 9.91e-81: 260: 21.90		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		436884 ACM2_HUMAN (19-485): 7.93e-83: 265: 26.38		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		574792 ADA2B_HUMAN (36-484): 5.84e-76: 247: 21.30		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		445809 ADA2A_HUMAN (2-484): 9.91e-81: 260: 21.90		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		574791 ADA2B_HUMAN (36-484): 5.84e-76: 247: 21.30		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		723749 DRD3_HUMAN (295-485): 1.36e-32: 130: 23.71		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		723748 DRD3_HUMAN (295-485): 1.36e-32: 130: 23.71		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		723747 DRD3_HUMAN (295-485): 1.36e-32: 130: 23.71		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		1307445 HRH3_HUMAN (373-483): 1.37e-14: 77.8: 32.14		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1307428 HRH3_HUMAN (373-483): 1.37e-14: 77.8: 32.14		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		723735 DRD3_HUMAN (295-485): 1.36e-32: 130: 23.71		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		429008 ADRB2_HUMAN (401-486): 1.68e-25: 110: 37.21		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38