HitPredict

Interactor 1: RORA (P35398)
Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
Gene: RORA

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.668

Property	Details
Experiments	16189514, 15604093, 16713569
Identification Methods	two hybrid, two hybrid pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 523 Hs			1 406
+	Hs
		907055 Q58EY0_HUMAN (64-514): 2.46e-121: 365: 61.32		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907112 RORB_HUMAN (59-514): 2.97e-121: 365: 61.30		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		846406 RORG_HUMAN (47-516): 2.64e-112: 344: 48.24		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		798685 Q58EY0_HUMAN (64-514): 2.46e-121: 365: 61.32		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		823807 NR2C2_HUMAN (3-523): 3.96e-104: 326: 20.89		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		823806 NR2C2_HUMAN (3-523): 3.96e-104: 326: 20.89		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		798611 NR2C2_HUMAN (3-523): 3.96e-104: 326: 20.89		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		907008 NR1H3_HUMAN (7-511): 4.54e-90: 284: 21.91		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		509930 VDR_HUMAN (54-516): 7.67e-89: 281: 22.60		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		730213 NR2C2_HUMAN (3-523): 3.96e-104: 326: 20.89		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		265859 NR1I2_HUMAN (53-511): 8.22e-84: 268: 20.95		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369311 ESR1_HUMAN (1-514): 1.1e-68: 233: 18.42		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		740491 PPARG_HUMAN (34-515): 3.3e-74: 245: 21.19		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369310 ESR1_HUMAN (1-514): 1.1e-68: 233: 18.42		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369145 ESR1_HUMAN (1-514): 1.1e-68: 233: 18.42		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		500362 RARB_HUMAN (1-175): 3.6e-54: 190: 39.43		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		487934 RARA_HUMAN (8-147): 9.91e-53: 187: 44.68		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369100 ESR1_HUMAN (1-514): 1.1e-68: 233: 18.42		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		823822 NR2C2_HUMAN (3-523): 3.96e-104: 326: 20.89		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Hs
		369327 ESR1_HUMAN (1-514): 1.1e-68: 233: 18.42		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64