HitPredict

Interactor 1: NMDE1 (P35436)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)
Gene: Grin2a

Interactor 2: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0042177 - negative regulation of protein catabolic process GO:0044877 - protein-containing complex binding GO:0098794 - postsynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1464 Mm			1 1186
+	Mm
		963721 NMDE2_MOUSE (3-1464): 0: 1537: 53.08		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		919690 NMDE2_MOUSE (3-1464): 0: 1537: 53.08		RAP1A_MOUSE (398-567): 1.81e-70: 235: 23.03
+	Mm
		620886 GRIA1_MOUSE (13-905): 0: 725: 18.97		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Rn
		585155 GRIA1_RAT (13-905): 0: 727: 18.97		AGAP2_RAT (1-1186): 0: 1019: 99.07
+	Mm
		723576 NMDZ1_MOUSE (6-940): 0: 695: 23.11		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		100188 F6YNQ1_MOUSE (82-905): 0: 678: 19.66		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		620948 GRIA2_MOUSE (14-870): 0: 676: 18.20		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Rn
		585178 GRIA2_RAT (14-870): 0: 677: 18.20		AGAP2_RAT (1-1186): 0: 1019: 99.07
+	Hs
		786742 GRIA2_HUMAN (14-870): 0: 679: 18.20		AGAP2_HUMAN (1-1147): 0: 987: 94.10
+	Mm
		723556 NMDZ1_MOUSE (6-940): 0: 695: 23.11		RAP1A_MOUSE (398-567): 1.81e-70: 235: 23.03