HitPredict

Interactor 1: NMDZ1 (P35438)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: Grin1

Interactor 2: ACTN2 (Q9JI91)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	10862698
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0042391 - regulation of membrane potential GO:0098839 - postsynaptic density membrane GO:0098978 - glutamatergic synapse
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 938 Mm			1 894
+	Rn
		723638 NMDZ1_RAT (1-938): 0: 920: 99.79		ACTN1_RAT (10-894): 0: 677: 80.00
+	Hs
		725646 NMDZ1_HUMAN (1-938): 0: 914: 99.04		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Hs
		211568 NMDZ1_HUMAN (1-938): 0: 914: 99.04		ACTN4_HUMAN (18-894): 0: 635: 78.23
+	Hs
		725650 NMDE2_HUMAN (4-938): 0: 634: 24.07		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Mm
		963773 NMDE2_MOUSE (4-938): 0: 628: 23.86		ACTN2_MOUSE (1-894): 0: 667: 100.00
+	Rn
		585223 GRIA4_RAT (7-888): 0: 661: 21.72		ACTN4_RAT (18-894): 0: 632: 77.78
+	Mm
		723587 NMDZ1_MOUSE (1-938): 0: 920: 100.00		SPTB2_MOUSE (228-770): 9.31e-15: 81.2: 12.48
+	Rn
		585221 GRIA4_RAT (7-888): 0: 661: 21.72		SPTN2_RAT (249-770): 2.26e-13: 76.6: 12.21
+	Hs
		786728 GRIA2_HUMAN (3-856): 0: 631: 21.55		SPTB2_HUMAN (228-770): 8.77e-15: 81.2: 12.48