HitPredict

Interactor 1: SCN1A (P35498)
Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)
Gene: SCN1A

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35044719
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2009 Hs			1 1319
+	Hs
		808322 SCN8A_HUMAN (1-2009): 0: 1879: 72.96		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808128 SCN5A_HUMAN (3-2003): 0: 1865: 61.26		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808340 SCNAA_HUMAN (6-2008): 0: 1747: 54.00		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Mm
		69865 SCN2A_MOUSE (1-2009): 0: 2078: 85.25		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Mm
		93274 SCN9A_MOUSE (4-2009): 0: 1989: 75.98		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Hs
		1055040 SCN5A_HUMAN (3-2003): 0: 1865: 61.26		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Mm
		93284 SCN8A_MOUSE (1-2009): 0: 1888: 72.81		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Mm
		93283 SCN5A_MOUSE (3-2003): 0: 1867: 61.08		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Mm
		93276 SCNAA_MOUSE (6-2008): 0: 1795: 53.66		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Hs
		723851 SCN1A_HUMAN (1-2009): 0: 2110: 100.00		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Mm
		69867 SCN2A_MOUSE (1-2009): 0: 2078: 85.25		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29
+	Hs
		1079738 SCN9A_HUMAN (4-2009): 0: 1996: 75.80		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Mm
		808358 SCN9A_MOUSE (4-2009): 0: 1989: 75.98		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29
+	Hs
		125457 SCN5A_HUMAN (3-2003): 0: 1865: 61.26		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		1055045 SCN5A_HUMAN (3-2003): 0: 1865: 61.26		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Mm
		808381 SCN8A_MOUSE (1-2009): 0: 1888: 72.81		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29
+	Mm
		808378 SCN5A_MOUSE (3-2003): 0: 1867: 61.08		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29
+	Mm
		808363 SCNAA_MOUSE (6-2008): 0: 1795: 53.66		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29
+	Mm
		93270 Q3UF73_MOUSE (1-201): 5.91e-113: 358: 87.56		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Mm
		808349 Q3UF73_MOUSE (1-201): 5.91e-113: 358: 87.56		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29