HitPredict

Interactor 1: MSX2 (P35548)
Homeobox protein MSX-2 (Homeobox protein Hox-8)
Gene: MSX2

Interactor 2: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 267 Hs			1 743
+	Hs
		658626 MSX1_HUMAN (38-267): 9.19e-37: 133: 57.14		TLE2_HUMAN (1-743): 0: 552: 100.00
+	Hs
		724224 MSX2_HUMAN (1-267): 6.78e-45: 153: 100.00		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		679098 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		679096 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		641379 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		641377 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		679097 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Hs
		641378 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Mm
		788279 NKX22_MOUSE (39-243): 9.75e-33: 122: 26.81		TLE3_MOUSE (1-743): 1.18e-166: 500: 64.55
+	Dm
		558356 TIN_DROME (68-226): 1.09e-35: 133: 37.04		GROU_DROME (1-743): 8.48e-144: 440: 54.69
+	Dm
		558366 UBX_DROME (4-203): 1.17e-31: 122: 23.30		GROU_DROME (1-743): 8.48e-144: 440: 54.69
+	Ce
		137664 HM19_CAEEL (137-228): 7.33e-35: 125: 41.30		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Ce
		137665 UNC4_CAEEL (89-267): 8.73e-34: 124: 18.68		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Hs
		724228 MSX2_HUMAN (1-267): 6.78e-45: 153: 100.00		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		679101 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		641385 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		234680 DLX3_HUMAN (31-258): 4.57e-39: 139: 27.71		TBL1X_HUMAN (542-742): 1.23e-45: 174: 15.60
+	Hs
		245566 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		TBL1X_HUMAN (542-742): 1.23e-45: 174: 15.60
+	Mm
		678773 HXA2_MOUSE (11-265): 1.25e-33: 126: 18.85		TLE6_MOUSE (444-743): 4.72e-48: 181: 34.31
+	Hs
		245563 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		TBL1X_HUMAN (542-742): 1.23e-45: 174: 15.60