HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	9111084, 30240640, 36931259, 9312143
Identification Methods	pull down, affinity chromatography technology, two hybrid, cross-linking study, competition binding
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1242 Hs			1 255
+	Mm
		724581 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		151760 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Dm
		955052 IRS1_DROME (6-914): 8.1e-87: 305: 18.00		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Hs
		910201 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		64684 RHG32_HUMAN (302-1240): 1.06e-36: 153: 13.08		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909455 ANK2_HUMAN (257-1242): 1.24e-31: 137: 12.26		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		297821 K0754_HUMAN (811-1241): 1.63e-24: 114: 8.73		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909712 OTOG_HUMAN (267-651): 8.41e-11: 69.2: 11.83		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00