Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1
Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.963 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 8388384, 8491186, 12173038, 22974441, 8536716, 21706016, 7486683 |
| Identification Methods | pull down, affinity chromatography technology, unspecified method, genetic interference, biophysical, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PH~SH3_1 |
| Common GO terms | GO:0001784 - phosphotyrosine residue binding GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 5 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
