HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	30240640, 11969417, 33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005159 - insulin-like growth factor receptor binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1242 Hs			1 246
+	Hs
		724526 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		724525 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Mm
		724581 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		1433E_MOUSE (1-244): 1.37e-141: 398: 62.71
+	Mm
		724580 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		1433G_MOUSE (1-246): 9.38e-138: 388: 86.99
+	Hs
		724528 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683169 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		646680 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		683873 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20
+	Mm
		724622 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		1433B_MOUSE (3-245): 9.94e-107: 310: 75.92
+	Dm
		955052 IRS1_DROME (6-914): 8.1e-87: 305: 18.00		1433E_DROME (1-243): 7.96e-141: 396: 63.37
+	Hs
		151760 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		151758 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		151776 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Dm
		664678 IRS1_DROME (6-914): 8.1e-87: 305: 18.00		1433Z_DROME (3-242): 8.23e-108: 312: 73.33
+	Hs
		151765 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		151720 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		151714 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		683852 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		647417 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		151721 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20