HitPredict

Interactor 1: IRS1 (P35569)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35115401
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1233 Mm			1 776
+	Hs
		724542 IRS1_HUMAN (1-1233): 1.17e-137: 452: 86.75		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Mm
		724626 IRS1_MOUSE (1-1233): 6.1e-156: 501: 100.00		CUL3_MOUSE (9-776): 0: 748: 30.35
+	Hs
		151791 IRS4_HUMAN (11-1058): 1.2e-81: 294: 23.32		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		724543 IRS1_HUMAN (1-1233): 1.17e-137: 452: 86.75		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		151794 IRS4_HUMAN (11-1058): 1.2e-81: 294: 23.32		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		151793 IRS4_HUMAN (11-1058): 1.2e-81: 294: 23.32		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		1042920 IRS2_HUMAN (13-1193): 2.42e-80: 291: 29.89		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		151792 IRS4_HUMAN (11-1058): 1.2e-81: 294: 23.32		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		1041192 SP130_HUMAN (289-1062): 8.72e-14: 78.4: 8.79		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1043209 SP130_HUMAN (289-1062): 8.72e-14: 78.4: 8.79		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1043571 SP130_HUMAN (289-1062): 8.72e-14: 78.4: 8.79		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		1042150 ATX2L_HUMAN (568-1233): 1.4e-12: 74.6: 9.91		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		1041909 TICRR_HUMAN (482-1185): 2.3e-12: 74.1: 12.55		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		1042076 KMT2C_HUMAN (234-868): 1.32e-10: 68.4: 9.33		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		1041464 SP130_HUMAN (289-1062): 8.72e-14: 78.4: 8.79		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Dm
		1359795 Q9VLS7_DROME (471-1229): 5.34e-09: 63: 10.15		Q9V475_DROME (9-776): 0: 714: 30.11