HitPredict

Interactor 1: MYH9 (P35579)
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Gene: MYH9

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33545068
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1960 Hs			1 577
+	Hs
		725092 MYH9_HUMAN (1-1923): 0: 1124: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		724994 MYH9_HUMAN (1-1923): 0: 1124: 100.00		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		724943 MYH9_HUMAN (1-1923): 0: 1124: 100.00		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		148460 MYH9_HUMAN (1-1923): 0: 1124: 100.00		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		724687 MYH9_HUMAN (1-1923): 0: 1124: 100.00		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		725035 MYH9_HUMAN (1-1923): 0: 1124: 100.00		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		724686 MYH9_HUMAN (1-1923): 0: 1124: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		528386 MYH6_HUMAN (979-1960): 2.36e-62: 239: 16.84		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		502925 MYH3_HUMAN (1063-1960): 8.04e-58: 224: 17.96		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		528432 MYH13_HUMAN (916-1960): 3.35e-66: 251: 17.46		MYH8_HUMAN (226-544): 1.02e-10: 67.2: 12.85
+	Mm
		93570 MYH9_MOUSE (954-1960): 2.59e-61: 235: 17.10		DESP_MOUSE (8-574): 5.01e-15: 81: 9.86
+	Hs
		528356 MYH6_HUMAN (979-1960): 2.36e-62: 239: 16.84		MYH6_HUMAN (226-544): 5.47e-12: 71: 15.05
+	Rn
		361106 MYH6_RAT (979-1960): 9.02e-62: 237: 16.62		MYH6_RAT (226-544): 4.65e-12: 71.4: 14.73
+	Hs
		148466 MYH11_HUMAN (723-1800): 1.94e-59: 229: 16.27		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		725097 MYH11_HUMAN (723-1800): 1.94e-59: 229: 16.27		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		502901 MYH3_HUMAN (1063-1960): 8.04e-58: 224: 17.96		MYH6_HUMAN (226-544): 5.47e-12: 71: 15.05
+	Hs
		502933 MYH3_HUMAN (1063-1960): 8.04e-58: 224: 17.96		MYH4_HUMAN (226-567): 2.08e-10: 66: 12.10
+	Hs
		522657 MYH4_HUMAN (1185-1960): 9.21e-49: 194: 14.34		MYH7_HUMAN (171-563): 8.39e-15: 80.3: 16.29
+	Hs
		528435 MYH8_HUMAN (1260-1959): 2.25e-50: 199: 16.76		MYH4_HUMAN (226-567): 2.08e-10: 66: 12.10