HitPredict

Interactor 1: AP2M (P35603)
AP-2 complex subunit mu (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) (Protein dumpy-23)
Gene: dpy-23

Interactor 2: Q9N4F3 (Q9N4F3)
AP complex subunit beta
Gene: apb-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19047463
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Adaptin_N, Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0006898 - receptor-mediated endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Ce			1 955
+	Hs
		925969 AP2M1_HUMAN (1-441): 0: 520: 80.95		AP2B1_HUMAN (1-954): 0: 857: 62.79
+	Hs
		1014061 AP2M1_HUMAN (1-441): 0: 520: 80.95		AP1B1_HUMAN (1-954): 0: 851: 62.75
+	Hs
		925992 AP1M1_HUMAN (2-440): 8.34e-180: 510: 36.96		AP2B1_HUMAN (1-954): 0: 857: 62.79
+	Hs
		1014074 AP1M1_HUMAN (2-440): 8.34e-180: 510: 36.96		AP1B1_HUMAN (1-954): 0: 851: 62.75
+	Hs
		926066 AP1M2_HUMAN (2-440): 3.31e-172: 491: 35.60		AP2B1_HUMAN (1-954): 0: 857: 62.79
+	Hs
		1014107 AP1M2_HUMAN (2-440): 3.31e-172: 491: 35.60		AP1B1_HUMAN (1-954): 0: 851: 62.75
+	Dm
		248295 O62530_DROME (1-441): 7.94e-178: 505: 81.35		Q24253_DROME (1-954): 0: 802: 66.18
+	Hs
		321614 AP2M1_HUMAN (1-441): 0: 520: 80.95		AP2A1_HUMAN (11-954): 0: 639: 16.22
+	Rn
		577193 AP2M1_RAT (1-441): 0: 520: 80.95		AP2A2_RAT (11-954): 0: 608: 16.06
+	Hs
		302192 AP2M1_HUMAN (1-441): 0: 520: 80.95		AP2A2_HUMAN (12-954): 0: 594: 14.83
+	Dm
		248292 O62530_DROME (1-441): 7.94e-178: 505: 81.35		AP2A_DROME (11-954): 0: 566: 14.16
+	Hs
		212655 AP2M1_HUMAN (1-441): 0: 520: 80.95		AP1G1_HUMAN (10-781): 1.72e-179: 542: 16.30
+	Hs
		212662 AP1M1_HUMAN (2-440): 8.34e-180: 510: 36.96		AP1G1_HUMAN (10-781): 1.72e-179: 542: 16.30
+	Mm
		612130 AP1M1_MOUSE (2-440): 4.54e-179: 508: 36.96		AP1G1_MOUSE (10-781): 1.18e-179: 543: 15.81
+	At
		187128 AP1M2_ARATH (2-440): 1.56e-178: 507: 37.56		AP1G1_ARATH (12-832): 2.44e-176: 536: 15.57
+	Hs
		212676 AP1M2_HUMAN (2-440): 3.31e-172: 491: 35.60		AP1G1_HUMAN (10-781): 1.72e-179: 542: 16.30
+	At
		1195473 AP1M1_ARATH (2-440): 6.65e-173: 493: 37.33		AP1G1_ARATH (12-832): 2.44e-176: 536: 15.57
+	Hs
		276382 AP2M1_HUMAN (1-441): 0: 520: 80.95		AP1G2_HUMAN (12-734): 1.71e-154: 476: 16.07
+	Ce
		725364 AP2M_CAEEL (1-441): 0: 536: 100.00		Q22601_CAEEL (14-562): 3.82e-141: 446: 20.23
+	Hs
		276398 AP1M2_HUMAN (2-440): 3.31e-172: 491: 35.60		AP1G2_HUMAN (12-734): 1.71e-154: 476: 16.07