Interactor 1: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2
Interactor 2: TITIN (Q8WZ42)
Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
Gene: TTN
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.86 | 1.00 | 0.929 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23414517, 11101506, 9501083, 16902413, 11846417 |
| Identification Methods | two hybrid, isothermal titration calorimetry, pull down, two hybrid fragment pooling approach, protein cross-linking with a bifunctional reagent |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CH~fn3, EF-hand_7~Pkinase, EFhand_Ca_insen~Titin_Z |
| Common GO terms | GO:0005509 - calcium ion binding GO:0005576 - extracellular region GO:0005829 - cytosol GO:0008307 - structural constituent of muscle GO:0030018 - Z disc and 4 others more... |
| Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
