HitPredict

Interactor 1: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20124353
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030175 - filopodium GO:0030864 - cortical actin cytoskeleton GO:0044325 - transmembrane transporter binding GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 817
+	Rn
		192529 ACTN1_RAT (8-894): 0: 660: 79.48		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Mm
		1163959 ACTN1_MOUSE (8-894): 0: 655: 79.26		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Mm
		1164079 ACTN2_MOUSE (1-894): 0: 655: 99.22		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Rn
		88555 D3ZCV0_RAT (20-894): 0: 638: 98.17		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Hs
		211646 ACTN4_HUMAN (18-894): 0: 619: 77.89		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		521600 ACTN1_HUMAN (8-894): 0: 658: 79.48		ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02
+	Hs
		725690 ACTN2_HUMAN (1-894): 0: 652: 100.00		ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02
+	Hs
		521581 ACTN1_HUMAN (8-894): 0: 658: 79.48		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Mm
		49891 A1BN54_MOUSE (8-894): 0: 660: 80.16		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		993277 ACTN3_HUMAN (25-894): 0: 633: 81.03		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		725643 ACTN2_HUMAN (1-894): 0: 652: 100.00		DLG4_HUMAN (438-714): 5.19e-28: 122: 16.38
+	Hs
		211617 ACTN4_HUMAN (18-894): 0: 619: 77.89		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		725649 ACTN2_HUMAN (1-894): 0: 652: 100.00		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Hs
		521540 ACTN1_HUMAN (8-894): 0: 658: 79.48		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		725654 ACTN2_HUMAN (1-894): 0: 652: 100.00		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		521598 ACTN1_HUMAN (8-894): 0: 658: 79.48		MAGI1_HUMAN (462-688): 1.9e-10: 66.9: 10.48
+	Mm
		1267826 ACTN2_MOUSE (1-894): 0: 655: 99.22		GRIP1_MOUSE (165-625): 9.17e-11: 67.7: 11.13
+	Hs
		993251 ACTN3_HUMAN (25-894): 0: 633: 81.03		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		211579 ACTN4_HUMAN (18-894): 0: 619: 77.89		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		211645 ACTN4_HUMAN (18-894): 0: 619: 77.89		MAGI1_HUMAN (462-688): 1.9e-10: 66.9: 10.48