HitPredict

Interactor 1: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Interactor 2: MYOZ2 (Q9NPC6)
Myozenin-2 (Calsarcin-1) (FATZ-related protein 2)
Gene: MYOZ2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	25416956, 25910212, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Calsarcin~Spectrin
Common GO terms	GO:0030018 - Z disc GO:0045214 - sarcomere organization GO:0051373 - FATZ binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 894 Hs			1 264
+	Hs
		521621 ACTN1_HUMAN (8-894): 0: 658: 79.48		MYOZ2_HUMAN (1-264): 2.9e-158: 441: 100.00
+	Hs
		211669 ACTN4_HUMAN (18-894): 0: 619: 77.89		MYOZ2_HUMAN (1-264): 2.9e-158: 441: 100.00
+	Hs
		521620 ACTN1_HUMAN (8-894): 0: 658: 79.48		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44
+	Hs
		725701 ACTN2_HUMAN (1-894): 0: 652: 100.00		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44
+	Hs
		993297 ACTN3_HUMAN (25-894): 0: 633: 81.03		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44
+	Hs
		211668 ACTN4_HUMAN (18-894): 0: 619: 77.89		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44