HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25192599
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pro_isomerase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 165
+	Hs
		727096 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28
+	Hs
		203502 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PPIH_HUMAN (2-164): 1.38e-84: 247: 53.85
+	Hs
		923645 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00
+	Hs
		967515 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28
+	Hs
		614297 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Hs
		614465 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Hs
		516744 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28