HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29884807
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 164
+	Hs
		1084353 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		726852 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		992865 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		703359 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CSTF2_HUMAN (10-110): 1.87e-25: 103: 25.47
+	Mm
		952207 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		726769 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		726792 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		266927 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		726675 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14
+	Hs
		726795 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Mm
		1207139 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		SRSF9_MOUSE (9-113): 9.03e-21: 86.6: 37.38
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Mm
		1207135 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		RBM4_MOUSE (11-88): 2.36e-18: 82.2: 28.21
+	Hs
		1029024 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		726791 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Mm
		882705 FUS_MOUSE (1-526): 6.91e-34: 136: 86.72		SRS10_MOUSE (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		726793 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	At
		186862 CYP59_ARATH (205-524): 5.51e-32: 130: 13.45		SR34_ARATH (5-88): 5.4e-23: 93.9: 45.35