HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	30110629, 33742100, 18509338
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 2414
+	Hs
		998942 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		967131 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		998651 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		516480 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		1271215 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		967540 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		967517 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		516745 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		726817 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		726907 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		726964 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		967421 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		BRD8_HUMAN (965-1183): 9.91e-16: 86: 19.18
+	Hs
		967173 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		967541 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PCLO_HUMAN (533-1087): 8.45e-12: 73.6: 11.83
+	Hs
		967313 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		516595 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13