HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25192599
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 2063
+	Hs
		967175 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		1057803 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		131713 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		BCL9_HUMAN (109-1440): 4.55e-36: 152: 9.92
+	Hs
		726649 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		726939 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Hs
		726817 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		820892 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		967541 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PCLO_HUMAN (89-2043): 5.64e-15: 83.7: 7.68
+	Hs
		967173 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		821102 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		867093 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SC24C_HUMAN (219-600): 6.59e-10: 66.7: 20.49
+	Hs
		1357564 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47
+	Hs
		1357832 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47
+	Hs
		820908 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		516406 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		516596 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Hs
		516595 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Hs
		516749 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47