HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: TNIP1 (Q15025)
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
Gene: TNIP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	36574265, 21988832
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 636
+	Hs
		967183 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00
+	Hs
		1031336 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00
+	Hs
		516525 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00
+	Hs
		1357565 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		SMC3_HUMAN (278-527): 2.28e-43: 169: 25.09
+	Mm
		882699 FUS_MOUSE (1-526): 6.91e-34: 136: 86.72		FTM_MOUSE (17-526): 3.12e-25: 113: 15.30
+	Hs
		149136 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Mm
		1142774 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		FTM_MOUSE (17-526): 3.12e-25: 113: 15.30
+	Hs
		148464 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		725096 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		MYH10_HUMAN (210-571): 5.78e-13: 74.6: 10.48
+	Hs
		726862 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		GRDN_HUMAN (154-540): 6.14e-09: 61.6: 9.92
+	Hs
		1137918 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		MRCKA_HUMAN (38-480): 1.13e-18: 92.8: 12.23
+	Mm
		665761 PABP1_MOUSE (184-382): 3.6e-12: 70.8: 12.44		FTM_MOUSE (17-526): 3.12e-25: 113: 15.30
+	Hs
		148894 PAP1L_HUMAN (182-382): 2.39e-13: 74.7: 13.43		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		148763 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		148334 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		1031397 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		148573 SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		516601 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		149282 PABP3_HUMAN (275-379): 5.23e-10: 63.9: 19.05		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Hs
		516673 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		CP250_HUMAN (63-566): 3.97e-11: 68.8: 11.57