HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: PABP2 (Q86U42)
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)
Gene: PABPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29884807, 35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 306
+	Hs
		967253 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PABP2_HUMAN (96-306): 9.35e-43: 150: 100.00
+	Mm
		892749 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		CIRBP_MOUSE (167-302): 1.7e-32: 119: 18.90
+	Hs
		726675 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		1199061 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PABP2_HUMAN (96-306): 9.35e-43: 150: 100.00
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		726795 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		854012 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		958264 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		RBM3_HUMAN (167-304): 1.15e-32: 119: 22.45
+	Hs
		212116 HTSF1_HUMAN (267-372): 6.19e-23: 104: 21.30		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		516744 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		967344 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DAZP1_HUMAN (163-285): 3.6e-21: 94.6: 21.14
+	Hs
		680441 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TIA1_HUMAN (167-278): 4.88e-19: 88.4: 15.93
+	Hs
		516768 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		1031507 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		853881 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		516425 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		516495 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		516339 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33