HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: DDX1 (Q92499)
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)
Gene: DDX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25192599, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003712 - transcription coregulator activity GO:0003723 - RNA binding GO:0005634 - nucleus and 2 others more... GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 740
+	Hs
		134145 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		133903 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		1271148 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571537 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		726967 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571333 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		133984 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		134252 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		967316 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		1271695 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		571409 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		571634 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		571648 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Hs
		134018 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		133858 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		726627 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00
+	Hs
		757802 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00
+	Hs
		757814 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00
+	Dm
		1360018 RBM8A_DROME (221-366): 1.61e-20: 90.4: 21.62		IF4A3_DROME (3-72): 1.44e-12: 72: 34.29
+	Hs
		516391 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00