HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: TNPO1 (Q92973)
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Gene: TNPO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	35271311, 22778397
Identification Methods	affinity chromatography technology, isothermal titration calorimetry, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 898
+	Hs
		967323 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TNPO1_HUMAN (1-898): 0: 663: 100.00
+	Hs
		726822 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		IMB1_HUMAN (21-862): 1.01e-87: 300: 16.15
+	Hs
		726680 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		XPO2_HUMAN (14-897): 9.98e-87: 299: 12.98
+	Dm
		185874 CAZ_DROME (175-481): 5.46e-34: 134: 38.91		IMB_DROME (15-862): 3.26e-83: 288: 17.78
+	Sc
		376762 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		IMB2_YEAST (9-895): 1.68e-104: 346: 31.22