HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: SPF45 (Q96I25)
Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)
Gene: RBM17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29884807
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 401
+	Hs
		1271164 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SPF45_HUMAN (1-401): 4.66e-158: 452: 100.00
+	Hs
		1294318 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		SPF45_HUMAN (1-401): 4.66e-158: 452: 100.00
+	Hs
		1054480 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76
+	Hs
		726815 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76
+	Hs
		1054669 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76
+	Hs
		1054716 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76
+	Hs
		1031328 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76
+	Dm
		1370593 Q9W424_DROME (265-407): 1.99e-18: 88.8: 19.61		Q9VM49_DROME (81-394): 1.42e-65: 220: 14.07
+	Hs
		516518 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		RBM39_HUMAN (88-394): 1.66e-72: 237: 13.76
+	Hs
		641874 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93
+	Dm
		1098207 CAZ_DROME (175-481): 5.46e-34: 134: 38.91		U2AF2_DROME (230-397): 1.9e-45: 163: 25.41
+	Hs
		641727 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93
+	Hs
		967500 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PUF60_HUMAN (131-398): 8.05e-33: 131: 16.67
+	Sp
		195263 UAP2_SCHPO (240-382): 1.33e-31: 127: 24.18		U2AF2_SCHPO (245-395): 3.59e-29: 120: 18.35
+	Hs
		212166 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		HTSF1_HUMAN (305-388): 4.02e-17: 85.4: 27.78
+	Hs
		212130 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		HTSF1_HUMAN (305-388): 4.02e-17: 85.4: 27.78
+	Hs
		641756 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93
+	Hs
		516364 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		U2AF2_HUMAN (244-397): 2.42e-36: 140: 23.93
+	Hs
		1031490 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		PUF60_HUMAN (131-398): 8.05e-33: 131: 16.67
+	Hs
		516730 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PUF60_HUMAN (131-398): 8.05e-33: 131: 16.67