HitPredict

Interactor 1: NU214 (P35658)
Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)
Gene: NUP214

Interactor 2: RAE1L (P78406)
mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41)
Gene: RAE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	35271311, 37516964, 26186194, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0006405 - RNA export from nucleus GO:0006406 - mRNA export from nucleus and 1 others more... GO:0006913 - nucleocytoplasmic transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2090 Hs			1 368
+	Hs
		857963 NUP98_HUMAN (1481-1973): 9.16e-17: 89.7: 15.60		RAE1L_HUMAN (1-368): 5.99e-98: 296: 100.00
+	Mm
		1161320 NUP98_MOUSE (1464-1973): 1.58e-16: 88.9: 16.03		RAE1L_MOUSE (17-368): 9.99e-93: 283: 99.15
+	Dm
		113998 M9PB30_DROME (249-923): 4.28e-15: 84.1: 9.37		Q9W1T0_DROME (30-357): 5.75e-83: 257: 36.59
+	Hs
		577699 SON_HUMAN (277-1824): 2.67e-46: 186: 9.42		NLE1_HUMAN (252-366): 5.64e-25: 107: 15.39
+	Hs
		245652 NCOR2_HUMAN (279-1978): 9.26e-33: 142: 8.93		TBL1X_HUMAN (2-160): 2.62e-39: 148: 17.14
+	Hs
		577684 SON_HUMAN (277-1824): 2.67e-46: 186: 9.42		SNR40_HUMAN (258-358): 1.55e-20: 93.1: 15.69
+	Hs
		1346974 NCOR2_HUMAN (279-1978): 9.26e-33: 142: 8.93		NLE1_HUMAN (252-366): 5.64e-25: 107: 15.39
+	Hs
		1056932 MDC1_HUMAN (423-1348): 9.84e-37: 155: 10.01		SNR40_HUMAN (258-358): 1.55e-20: 93.1: 15.69
+	Hs
		1288413 NCOR2_HUMAN (279-1978): 9.26e-33: 142: 8.93		SNR40_HUMAN (258-358): 1.55e-20: 93.1: 15.69
+	Hs
		1302927 MINT_HUMAN (283-1766): 1.23e-24: 115: 7.56		NLE1_HUMAN (252-366): 5.64e-25: 107: 15.39
+	Hs
		1288258 MINT_HUMAN (283-1766): 1.23e-24: 115: 7.56		SNR40_HUMAN (258-358): 1.55e-20: 93.1: 15.69
+	Hs
		903229 NCOA6_HUMAN (325-1617): 1.29e-17: 92.2: 8.74		WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75
+	Hs
		857957 NUP98_HUMAN (1481-1973): 9.16e-17: 89.7: 15.60		WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75
+	Dm
		1358850 NUP98_DROME (1756-2086): 1.04e-15: 85.9: 22.70		WDS_DROME (261-367): 1.51e-22: 98.9: 13.89
+	Hs
		903450 CIC_HUMAN (242-1032): 8.51e-14: 79.9: 9.89		WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75
+	Ce
		106866 NUP98_CAEEL (1676-2082): 3.16e-22: 107: 18.05		BUB3_CAEEL (15-188): 1.75e-13: 72.6: 12.69
+	Sc
		767629 NU116_YEAST (1635-2087): 1.93e-21: 104: 19.54		GLE2_YEAST (11-231): 4.21e-14: 74.7: 10.76
+	At
		1105208 NU98A_ARATH (1765-2087): 3.54e-16: 87.3: 20.54		RAE1_ARATH (11-200): 6.74e-16: 79.7: 11.17
+	Dm
		1362947 NUP98_DROME (1756-2086): 1.04e-15: 85.9: 22.70		RAE1_DROME (8-229): 1.73e-12: 69.6: 8.00
+	Hs
		211230 CIC_HUMAN (242-1032): 8.51e-14: 79.9: 9.89		BUB3_HUMAN (16-188): 5.39e-14: 74: 13.71