HitPredict

Interactor 1: HNF1B (P35680)
Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)
Gene: HNF1B

Interactor 2: PHS2 (Q9H0N5)
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
Gene: PCBD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 35140242
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 557 Hs			1 130
+	Mm
		655008 HNF1B_MOUSE (1-557): 1.16e-146: 435: 96.24		PHS_MOUSE (28-130): 3.38e-47: 149: 60.19
+	Hs
		727496 HNF1B_HUMAN (1-557): 6.73e-147: 436: 100.00		PHS_HUMAN (28-130): 8.31e-47: 148: 61.17
+	Hs
		595955 HNF1A_HUMAN (1-551): 2.16e-85: 279: 53.21		PHS2_HUMAN (1-130): 2.3e-57: 175: 100.00
+	Hs
		595917 HNF1A_HUMAN (1-551): 2.16e-85: 279: 53.21		PHS_HUMAN (28-130): 8.31e-47: 148: 61.17
+	Mm
		607525 HNF1A_MOUSE (1-551): 3.98e-78: 260: 53.03		PHS2_MOUSE (13-130): 9.33e-54: 166: 83.05
+	Mm
		607521 HNF1A_MOUSE (1-551): 3.98e-78: 260: 53.03		PHS_MOUSE (28-130): 3.38e-47: 149: 60.19