HitPredict

Interactor 1: NTRK1 (P35739)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Slow nerve growth factor receptor) (p140-TrkA) (Trk-A)
Gene: NTRK1

Interactor 2: NTRK2 (Q63604)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B)
Gene: NTRK2

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 27334657
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~I-set, I-set~LRR_8, LRR_8~LRR_8, LRRCT_2~LRR_8, LRR_8~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0000139 - Golgi membrane
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005030 - neurotrophin receptor activity
and 20 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 799
Rn

1 821
+ Mm
+ Rn
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+ Hs
+ Rn
+ Hs
+ Hs
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+ Hs
+ Hs
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+ Hs

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Last updated: 15 Jul 2024