HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: K1C17 (Q04695)
Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17)
Gene: KRT17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29859926
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0001533 - cornified envelope GO:0005829 - cytosol GO:0031424 - keratinization GO:0045095 - keratin filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 432
+	Hs
		408981 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C16_HUMAN (80-410): 1.7e-159: 460: 79.28
+	Hs
		359290 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C14_HUMAN (82-430): 1.15e-151: 440: 82.40
+	Hs
		408980 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C19_HUMAN (77-394): 1.39e-146: 424: 73.59
+	Hs
		408990 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C13_HUMAN (73-398): 8.48e-143: 417: 70.73
+	Hs
		49549 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		A1A4E9_HUMAN (73-398): 2.54e-142: 416: 70.43
+	Hs
		409000 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C15_HUMAN (83-426): 2.02e-141: 413: 68.66
+	Hs
		409071 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KT33B_HUMAN (77-395): 1.68e-118: 353: 59.88
+	Hs
		280508 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT34_HUMAN (77-395): 9.16e-117: 348: 58.62
+	Hs
		409094 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C24_HUMAN (79-391): 4.21e-114: 346: 62.26
+	Hs
		409137 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C25_HUMAN (78-424): 3.72e-114: 343: 53.13
+	Hs
		409054 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C17_HUMAN (1-432): 1.85e-109: 331: 100.00
+	Hs
		409135 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C27_HUMAN (4-431): 3.48e-107: 326: 49.55
+	Hs
		444534 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		K1C17_HUMAN (1-432): 1.85e-109: 331: 100.00
+	Hs
		409082 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H1_HUMAN (39-405): 3.5e-84: 265: 53.13
+	Hs
		409134 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C28_HUMAN (9-431): 1.11e-82: 263: 49.89
+	Hs
		409184 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT35_HUMAN (2-395): 1.01e-82: 263: 52.22
+	Hs
		280770 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT36_HUMAN (2-395): 8.29e-81: 258: 55.72
+	Hs
		409072 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H2_HUMAN (1-395): 5.85e-80: 255: 50.13
+	Hs
		280845 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT37_HUMAN (1-395): 7.16e-72: 235: 43.75
+	Hs
		280943 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT38_HUMAN (1-395): 1.59e-71: 234: 44.50