HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15703780
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0010629 - negative regulation of gene expression GO:0030335 - positive regulation of cell migration GO:0045766 - positive regulation of angiogenesis
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1356 Hs			1 770
+	Hs
		729622 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Mm
		729405 VGFR3_MOUSE (28-1348): 0: 785: 42.85		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		601474 FGFR2_HUMAN (1-231): 3.47e-24: 112: 9.57		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		572592 VGFR1_HUMAN (1-131): 5.1e-20: 99.3: 13.38		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		609197 FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		507894 FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		499238 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		572594 VGFR1_HUMAN (1-131): 5.1e-20: 99.3: 13.38		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		452369 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		499250 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		499239 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		601481 FGFR2_HUMAN (1-231): 3.47e-24: 112: 9.57		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		601477 FGFR2_HUMAN (1-231): 3.47e-24: 112: 9.57		STA5A_HUMAN (1-734): 0: 745: 30.42