HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: VEGFC (P49767)
Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)
Gene: VEGFC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 20145116, 18593464
Identification Methods x-ray crystallography, unspecified method, pull down, light scattering, isothermal titration calorimetry, surface plasmon resonance, molecular sieving
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PDGF~ig
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005576 - extracellular region
GO:0008284 - positive regulation of cell population proliferation
GO:0038084 - vascular endothelial growth factor signaling pathway
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1356
Hs

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Last updated: 15 Jul 2024