HitPredict

Interactor 1: VPS21 (P36017)
Vacuolar protein sorting-associated protein 21 (GTP-binding protein YPT51) (Vacuolar protein-targeting protein 12)
Gene: VPS21

Interactor 2: VPS8 (P39702)
Vacuolar protein sorting-associated protein 8 (Vacuolar protein-targeting protein 8)
Gene: VPS8

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	23417307, 21325627, 23840658, 19828734, 20173035, 22157956, 22593205
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005770 - late endosome GO:0006623 - protein targeting to vacuole GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 210 Sc			1 1274
+	Sc
		731245 YPT53_YEAST (7-210): 8.68e-75: 226: 56.94		VPS8_YEAST (1-1274): 0: 1966: 100.00
+	Sc
		731216 YPT52_YEAST (9-208): 5.36e-57: 181: 48.25		VPS8_YEAST (1-1274): 0: 1966: 100.00
+	Hs
		914209 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		VPS8_HUMAN (521-1269): 0: 651: 19.17
+	Hs
		592367 RAB5A_HUMAN (5-209): 3.43e-64: 199: 54.63		VPS8_HUMAN (521-1269): 0: 651: 19.17
+	Hs
		844615 RAB5C_HUMAN (5-209): 9.43e-64: 198: 54.15		VPS8_HUMAN (521-1269): 0: 651: 19.17
+	Dm
		1358736 RAB5_DROME (9-172): 1.51e-64: 200: 64.63		VPS8_DROME (514-1268): 0: 577: 21.04