HitPredict

Interactor 1: SWD2 (P36104)
COMPASS component SWD2 (Complex proteins associated with SET1 protein SWD2) (Set1C component SWD2)
Gene: SWD2

Interactor 2: SWD3 (P38123)
COMPASS component SWD3 (Complex proteins associated with SET1 protein SWD3) (Set1C component SWD3)
Gene: SWD3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	11742990, 32358498, 16554755, 37968396, 21179020
Identification Methods	coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000723 - telomere maintenance GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0031509 - subtelomeric heterochromatin formation GO:0048188 - Set1C/COMPASS complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 329 Sc			1 315
+	Hs
		1281292 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		FBXW7_HUMAN (1-308): 2.78e-72: 237: 18.91
+	Sp
		195045 SWD2_SCHPO (1-325): 2.8e-97: 293: 32.32		SWD3_SCHPO (90-314): 2.27e-41: 149: 22.03
+	Hs
		903418 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		WDR5_HUMAN (4-216): 3.22e-55: 184: 19.09
+	Hs
		903551 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		WDR5_HUMAN (4-216): 3.22e-55: 184: 19.09
+	Hs
		903428 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		WDR5_HUMAN (4-216): 3.22e-55: 184: 19.09
+	Hs
		792949 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		WDR5_HUMAN (4-216): 3.22e-55: 184: 19.09
+	Hs
		197071 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		PRP4_HUMAN (94-313): 5.33e-43: 156: 13.97
+	Hs
		903349 WDR5B_HUMAN (146-328): 9.18e-44: 154: 14.21		WDR5_HUMAN (4-216): 3.22e-55: 184: 19.09
+	Sc
		630844 NLE1_YEAST (2-228): 2.98e-53: 184: 10.82		NLE1_YEAST (134-313): 4.45e-41: 151: 18.13
+	Hs
		196984 PRP4_HUMAN (115-328): 4.42e-39: 146: 11.21		WDR5_HUMAN (4-216): 3.22e-55: 184: 19.09
+	Sp
		999842 TUP12_SCHPO (104-328): 1.17e-49: 176: 17.60		TUP11_SCHPO (121-312): 7.57e-41: 151: 19.07
+	Dm
		1358859 WDS_DROME (3-232): 4.95e-61: 200: 11.81		FBXW7_DROME (2-162): 2.48e-30: 122: 18.61
+	Hs
		1103007 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		SMU1_HUMAN (136-314): 1.52e-24: 105: 21.23
+	Hs
		196910 PRP4_HUMAN (115-328): 4.42e-39: 146: 11.21		PRP4_HUMAN (94-313): 5.33e-43: 156: 13.97
+	Hs
		1346954 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		NLE1_HUMAN (222-313): 1.65e-13: 72.7: 14.89
+	Hs
		1288390 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		WDR3_HUMAN (8-217): 4.17e-15: 77.8: 25.35
+	Dm
		1358845 WDS_DROME (3-232): 4.95e-61: 200: 11.81		WDS_DROME (220-312): 6.13e-10: 61.6: 9.47
+	Hs
		792935 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		LIS1_HUMAN (231-314): 8.47e-12: 67.4: 19.77
+	Mm
		925836 LIS1_MOUSE (2-184): 1.63e-52: 179: 11.82		LIS1_MOUSE (231-314): 7.94e-12: 67.4: 19.77