HitPredict

Interactor 1: SWD2 (P36104)
COMPASS component SWD2 (Complex proteins associated with SET1 protein SWD2) (Set1C component SWD2)
Gene: SWD2

Interactor 2: SWD1 (P39706)
COMPASS component SWD1 (Complex proteins associated with SET1 protein SWD1) (Set1C component SWD1)
Gene: SWD1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	11742990, 16429126, 37968396
Identification Methods	coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000723 - telomere maintenance GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0031509 - subtelomeric heterochromatin formation GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 329 Sc			1 426
+	Sp
		194052 SWD2_SCHPO (1-325): 2.8e-97: 293: 32.32		SWD1_SCHPO (1-405): 5.34e-95: 292: 35.29
+	Dr
		1193337 Q7ZTX2_DANRE (3-228): 3.59e-60: 197: 11.16		Q7ZUU9_DANRE (1-397): 7.04e-78: 252: 28.15
+	Hs
		1070736 WDR5B_HUMAN (146-328): 9.18e-44: 154: 14.21		RBBP5_HUMAN (1-397): 2.09e-78: 254: 28.15
+	Hs
		1288273 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		WDR83_HUMAN (7-346): 7.02e-66: 214: 13.78
+	Hs
		254111 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		WDR1_HUMAN (10-250): 8.34e-37: 143: 24.10
+	Sp
		999842 TUP12_SCHPO (104-328): 1.17e-49: 176: 17.60		TUP11_SCHPO (152-425): 2.83e-43: 161: 12.72
+	Hs
		903418 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		WDR5_HUMAN (245-419): 2.37e-22: 98.8: 11.74
+	Hs
		1103007 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		SMU1_HUMAN (13-340): 3.07e-20: 94.9: 17.16
+	Hs
		792935 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		LIS1_HUMAN (210-422): 6.1e-33: 130: 9.86
+	Mm
		925836 LIS1_MOUSE (2-184): 1.63e-52: 179: 11.82		LIS1_MOUSE (210-422): 4.7e-33: 130: 9.86
+	Hs
		1346954 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		NLE1_HUMAN (243-415): 3.68e-22: 100: 10.92
+	Hs
		903551 NLE1_HUMAN (60-328): 8.95e-58: 195: 11.54		WDR5_HUMAN (245-419): 2.37e-22: 98.8: 11.74
+	Dm
		1358859 WDS_DROME (3-232): 4.95e-61: 200: 11.81		FBXW7_DROME (8-148): 6.53e-18: 88.4: 15.14
+	Sc
		630844 NLE1_YEAST (2-228): 2.98e-53: 184: 10.82		NLE1_YEAST (243-422): 2.36e-23: 104: 10.50
+	Hs
		903428 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		WDR5_HUMAN (245-419): 2.37e-22: 98.8: 11.74
+	Hs
		1281292 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		FBXW7_HUMAN (3-95): 3.57e-11: 67.2: 14.43
+	Hs
		792949 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		WDR5_HUMAN (245-419): 2.37e-22: 98.8: 11.74
+	Dm
		1358845 WDS_DROME (3-232): 4.95e-61: 200: 11.81		WDS_DROME (300-425): 8.25e-12: 68: 7.14
+	Hs
		197071 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		PRP4_HUMAN (243-405): 2.82e-12: 70.3: 12.28
+	Hs
		903349 WDR5B_HUMAN (146-328): 9.18e-44: 154: 14.21		WDR5_HUMAN (245-419): 2.37e-22: 98.8: 11.74