HitPredict

Interactor 1: SWD2 (P36104)
COMPASS component SWD2 (Complex proteins associated with SET1 protein SWD2) (Set1C component SWD2)
Gene: SWD2

Interactor 2: YSH1 (Q06224)
Endoribonuclease YSH1 (EC 3.1.27.-) (Yeast 73 kDa homolog 1) (mRNA 3'-end-processing protein YSH1)
Gene: YSH1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	11742990, 12819204, 16554755, 16429126, 37968396, 21179020
Identification Methods	coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled GO:0031126 - sno(s)RNA 3'-end processing
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 329 Sc			1 779
+	Sp
		142962 YIQ4_SCHPO (11-329): 2.81e-100: 300: 29.43		YSH1_SCHPO (2-778): 0: 629: 47.11
+	Hs
		1281466 FBXW7_HUMAN (2-273): 5.15e-64: 216: 13.97		CPSF3_HUMAN (1-778): 0: 694: 37.21
+	Hs
		793039 LIS1_HUMAN (2-184): 2.22e-52: 179: 11.82		CPSF3_HUMAN (1-778): 0: 694: 37.21
+	Sp
		251803 YIQ4_SCHPO (11-329): 2.81e-100: 300: 29.43		CFT2_SCHPO (26-546): 1.02e-86: 293: 18.00
+	Sc
		732692 SWD2_YEAST (1-329): 7.44e-86: 263: 100.00		CFT2_YEAST (15-546): 2.92e-90: 304: 14.74
+	Hs
		903574 WDR5_HUMAN (185-328): 3.72e-32: 124: 16.67		CPSF2_HUMAN (6-729): 5.19e-127: 399: 18.13
+	Hs
		1288334 SNR40_HUMAN (2-227): 1.86e-55: 186: 18.57		INT9_HUMAN (9-535): 9.34e-98: 319: 16.80
+	Sc
		732691 SWD2_YEAST (1-329): 7.44e-86: 263: 100.00		SYC1_YEAST (569-779): 1.58e-37: 140: 33.65