HitPredict

Interactor 1: DID4 (P36108)
DOA4-independent degradation protein 4 (ESCRT-III complex subunit VPS2) (Vacuolar protein-sorting-associated protein 2) (Vacuolar protein-targeting protein 14)
Gene: DID4

Interactor 2: IST1 (P53843)
Vacuolar protein sorting-associated protein IST1 (Increased sodium tolerance protein 1)
Gene: IST1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	31273031, 35445263, 28183979
Identification Methods	affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0015031 - protein transport
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 232 Sc			1 298
+	Sc
		732545 VPS24_YEAST (11-229): 1.98e-40: 139: 22.83		IST1_YEAST (1-298): 9.42e-92: 275: 100.00
+	Sc
		865241 DID2_YEAST (24-229): 6.89e-30: 112: 17.96		IST1_YEAST (1-298): 9.42e-92: 275: 100.00
+	Dm
		116109 Q9VBI3_DROME (4-205): 3.75e-44: 150: 45.55		M9PHL4_DROME (7-197): 4.03e-59: 195: 29.74
+	Dm
		116116 Q9VRJ5_DROME (3-211): 2.24e-44: 149: 25.36		M9PHL4_DROME (7-197): 4.03e-59: 195: 29.74
+	Dm
		116112 Q9VN02_DROME (10-229): 9.7e-43: 145: 22.27		M9PHL4_DROME (7-197): 4.03e-59: 195: 29.74
+	Ce
		106471 Q9TXI3_CAEEL (24-210): 7.72e-36: 127: 20.32		G5EDV6_CAEEL (9-195): 8.33e-60: 198: 31.25
+	Dm
		116105 Q95SH2_DROME (25-230): 2.74e-35: 126: 22.82		M9PHL4_DROME (7-197): 4.03e-59: 195: 29.74
+	Hs
		867068 CHM1A_HUMAN (24-229): 5.01e-33: 119: 19.90		IST1_HUMAN (11-204): 5.78e-62: 201: 32.14
+	Dm
		1279489 Q95SH2_DROME (25-230): 2.74e-35: 126: 22.82		Q9VRY6_DROME (7-197): 1.26e-57: 192: 29.74
+	Hs
		867047 CHM1B_HUMAN (25-205): 4.16e-32: 117: 22.10		IST1_HUMAN (11-204): 5.78e-62: 201: 32.14