HitPredict

Interactor 1: DID4 (P36108)
DOA4-independent degradation protein 4 (ESCRT-III complex subunit VPS2) (Vacuolar protein-sorting-associated protein 2) (Vacuolar protein-targeting protein 14)
Gene: DID4

Interactor 2: VPS60 (Q03390)
Vacuolar protein-sorting-associated protein 60 (Charged multivesicular body protein 5)
Gene: VPS60

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	31273031, 35445263
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0005737 - cytoplasm GO:0005771 - multivesicular body GO:0015031 - protein transport
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 232 Sc			1 229
+	At
		98407 VP241_ARATH (1-229): 3.07e-46: 154: 24.45		F4JXR3_ARATH (1-229): 7.07e-52: 170: 20.07
+	Ce
		1090380 Q9U2F6_CAEEL (4-231): 3.21e-53: 173: 42.44		Q18886_CAEEL (2-222): 2.41e-42: 144: 19.46
+	At
		1013158 VPS2B_ARATH (5-230): 5.98e-46: 154: 33.19		VP601_ARATH (1-229): 2.23e-48: 160: 22.36
+	At
		1322582 VP241_ARATH (1-229): 3.07e-46: 154: 24.45		VP601_ARATH (1-229): 2.23e-48: 160: 22.36
+	Sc
		732845 DID4_YEAST (1-232): 1.73e-59: 188: 100.00		SNF7_YEAST (4-226): 1.29e-34: 125: 20.98
+	Sc
		732861 DID4_YEAST (1-232): 1.73e-59: 188: 100.00		VPS20_YEAST (6-227): 1.29e-33: 122: 17.12
+	Hs
		208864 CHM2A_HUMAN (4-231): 4.05e-47: 156: 39.04		CHMP5_HUMAN (1-225): 7.1e-43: 146: 28.44
+	At
		1276050 VPS2C_ARATH (5-229): 4.76e-49: 161: 30.67		VP322_ARATH (1-227): 5e-38: 133: 19.30
+	Hs
		208860 CHM2A_HUMAN (4-231): 4.05e-47: 156: 39.04		CHM4B_HUMAN (15-220): 3.6e-38: 133: 19.42
+	At
		287069 VPS2C_ARATH (5-229): 4.76e-49: 161: 30.67		VP321_ARATH (1-220): 8.32e-36: 127: 16.82
+	At
		1013168 VPS2B_ARATH (5-230): 5.98e-46: 154: 33.19		VP322_ARATH (1-227): 5e-38: 133: 19.30
+	At
		287066 VPS2B_ARATH (5-230): 5.98e-46: 154: 33.19		VP321_ARATH (1-220): 8.32e-36: 127: 16.82
+	At
		287071 VP241_ARATH (1-229): 3.07e-46: 154: 24.45		VP321_ARATH (1-220): 8.32e-36: 127: 16.82
+	At
		1209623 VPS2C_ARATH (5-229): 4.76e-49: 161: 30.67		VP201_ARATH (1-228): 6.9e-32: 117: 19.30
+	At
		1276045 VPS2C_ARATH (5-229): 4.76e-49: 161: 30.67		VP202_ARATH (1-228): 8.39e-31: 114: 20.44
+	At
		1209625 VP241_ARATH (1-229): 3.07e-46: 154: 24.45		VP201_ARATH (1-228): 6.9e-32: 117: 19.30
+	At
		1322581 VP241_ARATH (1-229): 3.07e-46: 154: 24.45		VP202_ARATH (1-228): 8.39e-31: 114: 20.44
+	At
		1013164 VPS2A_ARATH (3-230): 6.92e-57: 182: 43.86		VPS2B_ARATH (8-194): 1.08e-12: 66.8: 13.90
+	At
		1013141 VPS2B_ARATH (5-230): 5.98e-46: 154: 33.19		VPS2B_ARATH (8-194): 1.08e-12: 66.8: 13.90