HitPredict - High confidence protein-protein interactions

Interactor 1: TAP1 (P36370)
Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide transporter TAP1)
Gene: TAP1

Interactor 2: TAP2 (P36372)
Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3)
Gene: TAP2

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	18802093
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	ABC_membrane~ABC_membrane, ABC_membrane~ABC_tran, ABC_tran~ABC_tran
Common GO terms	GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0005789 - endoplasmic reticulum membrane GO:0015833 - peptide transport GO:0015031 - protein transport and 20 others more... GO:0015433 - ABC-type peptide antigen transporter activity GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity GO:0019885 - antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0023029 - MHC class Ib protein binding GO:0042270 - protection from natural killer cell mediated cytotoxicity GO:0042288 - MHC class I protein binding GO:0042605 - peptide antigen binding GO:0042803 - protein homodimerization activity GO:0042824 - MHC class I peptide loading complex GO:0042825 - TAP complex GO:0043531 - ADP binding GO:0044877 - protein-containing complex binding GO:0046978 - TAP1 binding GO:0046979 - TAP2 binding GO:0046980 - tapasin binding GO:0046872 - metal ion binding GO:0046967 - cytosol to endoplasmic reticulum transport GO:0046968 - peptide antigen transport GO:0055085 - transmembrane transport
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1	725
Rn

1	703

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024