HitPredict

Interactor 1: TRI23 (P36406)
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
Gene: TRIM23

Interactor 2: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	28681414, 33957127, 15684077, 16413270, 20724660
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction, ubiquitination reaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 147
+	Hs
		734819 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		734563 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		734581 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		734733 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2E2_HUMAN (4-146): 1.76e-74: 222: 65.04
+	Hs
		734564 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		734571 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53
+	Hs
		895769 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		1356055 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		1151762 Q6GX22_HUMAN (23-400): 6.72e-69: 237: 19.60		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		849480 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		919896 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		895945 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		1297378 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E2_HUMAN (4-146): 1.76e-74: 222: 65.04
+	Hs
		1282363 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E3_HUMAN (4-146): 1.05e-73: 220: 65.73
+	Hs
		851905 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		896562 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53
+	Hs
		896464 Q6GX22_HUMAN (23-400): 6.72e-69: 237: 19.60		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53