HitPredict

Interactor 1: TRI23 (P36406)
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
Gene: TRIM23

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28681414
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 151
+	Hs
		734819 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		734563 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		734581 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		734570 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		734733 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		734564 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		895769 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1356055 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		1151762 Q6GX22_HUMAN (23-400): 6.72e-69: 237: 19.60		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849480 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919896 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895945 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1297378 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1282363 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851905 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Zm
		16119 A0A1D6HW42_MAIZE (392-569): 1.27e-60: 201: 56.74		A0A1D6GKI5_MAIZE (6-150): 3.19e-38: 130: 40.00
+	Sc
		350911 YPT1_YEAST (397-572): 5.5e-59: 197: 17.13		UBC7_YEAST (3-117): 4.11e-18: 77.8: 38.28