HitPredict

Interactor 1: TRI23 (P36406)
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
Gene: TRIM23

Interactor 2: TB22B (Q9NU19)
TBC1 domain family member 22B
Gene: TBC1D22B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.50	0.654

Property	Details
Experiments	25416956, 32296183, unassigned1304, 31515488, 29892012
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 505
+	Hs
		913139 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		TB22B_HUMAN (1-505): 9.73e-165: 477: 100.00
+	Hs
		1345844 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		TB22B_HUMAN (1-505): 9.73e-165: 477: 100.00
+	Hs
		950566 ARF1_HUMAN (390-569): 5.89e-71: 227: 57.22		TB22B_HUMAN (1-505): 9.73e-165: 477: 100.00
+	Hs
		950725 ARF5_HUMAN (392-568): 1.63e-69: 223: 55.37		TB22B_HUMAN (1-505): 9.73e-165: 477: 100.00
+	Hs
		897408 ARF3_HUMAN (390-569): 5.58e-61: 201: 56.67		TB22B_HUMAN (1-505): 9.73e-165: 477: 100.00
+	Hs
		912934 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		TB10B_HUMAN (18-502): 2.38e-83: 276: 15.22
+	Dm
		778397 ARF6_DROME (399-564): 1.89e-85: 264: 54.82		Q8IPP5_DROME (33-503): 7.33e-76: 262: 17.14
+	Dm
		778412 ARF6_DROME (399-564): 1.89e-85: 264: 54.82		Q9VNG9_DROME (33-503): 7.76e-76: 261: 17.14
+	Hs
		913204 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		RBGP1_HUMAN (104-493): 4.58e-71: 246: 19.85
+	Hs
		913085 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		TB10A_HUMAN (114-504): 7.31e-70: 233: 15.23
+	Sc
		503151 ARF1_YEAST (391-568): 4.41e-70: 225: 53.93		GYP1_YEAST (14-433): 3.93e-82: 269: 34.17
+	Os
		1130874 Q7XHP7_ORYSJ (401-568): 1.87e-60: 201: 15.61		Q5SMT0_ORYSJ (12-489): 2.28e-88: 286: 19.64
+	Os
		1130875 Q84TA8_ORYSJ (401-568): 1.77e-60: 201: 15.61		Q5SMT0_ORYSJ (12-489): 2.28e-88: 286: 19.64
+	Sc
		350927 YPT1_YEAST (397-572): 5.5e-59: 197: 17.13		GYP1_YEAST (14-433): 3.93e-82: 269: 34.17
+	Hs
		894747 RAB8A_HUMAN (397-573): 8.21e-59: 196: 19.78		TBC9B_HUMAN (50-502): 2.33e-78: 268: 15.15
+	Hs
		894727 RAB8A_HUMAN (397-573): 8.21e-59: 196: 19.78		TBC8B_HUMAN (49-480): 1.24e-77: 265: 14.64
+	Hs
		894778 RAB8A_HUMAN (397-573): 8.21e-59: 196: 19.78		TBC15_HUMAN (123-496): 8.36e-80: 264: 20.41
+	Hs
		918951 RAB1A_HUMAN (397-569): 2.41e-61: 203: 15.17		TBC17_HUMAN (78-500): 2.95e-72: 243: 18.95
+	Hs
		894809 RAB8A_HUMAN (397-573): 8.21e-59: 196: 19.78		TBC17_HUMAN (78-500): 2.95e-72: 243: 18.95