HitPredict

Interactor 1: MP2K2 (P36506)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: Map2k2

Interactor 2: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22871113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 400 Rn			1 810
+	Rn
		448416 KPCE_RAT (3-354): 1.71e-111: 344: 21.68		UBC_RAT (1-810): 0: 1000: 100.00
+	Hs
		475390 AKT1_HUMAN (14-351): 4.81e-127: 376: 18.49		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475424 MP2K2_HUMAN (1-400): 7.05e-123: 362: 94.00		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475699 MP2K5_HUMAN (45-395): 2.23e-103: 314: 39.83		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475462 MP2K4_HUMAN (2-396): 2.58e-101: 307: 31.30		UBC_HUMAN (1-533): 0: 662: 99.81
+	At
		1091641 KIN10_ARATH (71-352): 1.28e-128: 381: 22.22		UBQ3_ARATH (533-801): 1.64e-106: 330: 89.22
+	At
		955189 KIN11_ARATH (71-348): 7.42e-125: 371: 24.11		UBQ3_ARATH (533-801): 1.64e-106: 330: 89.22
+	At
		1092272 M2K2_ARATH (50-386): 6.42e-112: 333: 35.40		UBQ3_ARATH (533-801): 1.64e-106: 330: 89.22
+	Hs
		681773 AKT1_HUMAN (14-351): 4.81e-127: 376: 18.49		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Hs
		625332 CDK2_HUMAN (69-375): 1.49e-126: 368: 24.60		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Hs
		923962 KPCE_HUMAN (3-354): 1.02e-112: 347: 21.43		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Hs
		474935 AKT1_HUMAN (14-351): 4.81e-127: 376: 18.49		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		474936 AKT2_HUMAN (28-365): 9.02e-127: 375: 19.95		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		474923 KAPCG_HUMAN (62-368): 7.62e-123: 360: 20.99		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		397911 CDK3_HUMAN (69-375): 6.34e-113: 334: 22.68		ISG15_HUMAN (228-380): 7.21e-29: 115: 32.69
+	Hs
		475012 STK4_HUMAN (41-377): 3.45e-111: 336: 29.91		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70